What Are Neuromodulators and How Do They Work in Facial Aesthetics?

News Blog, Tips and Aesthetic Care

Posted by Dr. Miguel Fernández Calderón: 20/03/2024


Finding treatment options to look your best is one of the primary goals of aesthetic medicine, yet it’s increasingly common to seek solutions that don’t require entering an operating room. In the case of wrinkles or expression lines, there is a very effective option: neuromodulators. But what are they and how do they work in facial aesthetics? Keep reading and you’ll find the answer here!

What are neuromodulators

Neuromodulators are chemical substances that have a direct effect on the nervous system, regulating neuronal activity. In the field of aesthetic medicine, when we speak of neuromodulators, we’re referring to botulinum toxin used for skin rejuvenation, which works by eliminating expression lines and reducing wrinkles.

Origin of neuromodulators

In the 1920s, acetylcholine was discovered, considered one of the first neuromodulators. Later, between 1950 and 1960, scientists identified other neuromodulators such as dopamine, serotonin, and noradrenaline.

In the 1970s, botulinum toxin was discovered when scientists of that era investigated and conducted tests on the properties of certain toxins. However, it wasn’t until between 1980 and 1990 that its use became widespread, and this neuromodulator began to be applied in the field of aesthetic medicine.

Main types on the market

There are a variety of facial surgeries to improve various aspects of the face, but if we’re talking about eliminating wrinkles and expression lines without resorting to surgery, you should know that the main botulinum toxins used for this purpose are Botox, Dysport, Jeuveau, and Xeomin. Let’s review each one in detail.

  • Botox. It is composed of botulinum toxin type A, specifically Onabotulinumtoxin. It works by paralyzing the muscle for a set period, helping to reduce wrinkles and prevent the formation of new ones. It is widely used around the eyes and between the eyebrows.
  • Dysport. Also known as Abobotulinumtoxin A, it acts on the muscle in the injection area by temporarily relaxing the muscle, allowing the skin covering it to soften. It is especially used for vertical wrinkles on the forehead, between the brows, and crow’s feet.
  • Jeuveau. It is a purified botulinum toxin with a relaxing effect on dynamic wrinkles.
  • Xeomin. This neuromodulator contains no additives or preservatives and is ideal for those who have experienced adverse reactions when using any of the other neuromodulators on the market.
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How neuromodulators work in aesthetics

Mechanism of action on the skin

Neuromodulators are derived from the bacterium Clostridium Botulinum, and when injected into the body, they locate themselves in areas where nerves communicate with muscles. In the case of the face, neuromodulators prevent, for a limited time, muscles from releasing acetylcholine, which is a neurotransmitter whose function is to contract muscles.

As a result of this action, the facial muscles that receive the neuromodulator begin to relax, and with this comes a reduction in the appearance of fine lines and dynamic wrinkles, which originate from repetitive muscle movements. In the case of the face, these can appear from constantly frowning or from the action of closing and opening the eyes. By preventing muscle contraction and smoothing wrinkles and expression lines, it is possible to achieve firmer-looking skin and a rejuvenated face.

Unlike what happens with a facelift, this type of procedure eliminates wrinkles and expression lines without resorting to the scalpel.

Treatment areas and applications

Among the aesthetic concerns of the face that can be treated with neuromodulators, we find:

  • Horizontal lines that form on the forehead, caused by raising the eyebrows.
  • Vertical lines located between the eyebrows, generally caused by frowning.
  • Fine lines that appear around the eyes, also known as crow’s feet, which are produced when smiling or squinting.
  • Wrinkles on the sides of the nose, or bunny lines. Also caused by smiling or making grimaces that involve excessive movement or wrinkling of the nose.

Benefits of neuromodulator treatments

The benefits of using neuromodulator injections to eliminate expression lines and wrinkles become evident when the patient achieves a more youthful appearance.

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Immediate and long-term effects

Neuromodulator injections, such as botulinum toxin, are a minimally invasive aesthetic procedure, which represents a major advantage in terms of achieving immediate results and quick recovery.

From the first day of treatment, changes can be seen, and within a few days the patient can already see the final results, which can last up to 4 months.

Prevention of signs of aging

When facial muscles relax thanks to the effects of neuromodulators, it is also possible to prevent the formation of new wrinkles.

One of the functions of neuromodulators is to prevent the formation of dynamic expression lines. Over time, and without preventive treatment, these can become static wrinkles—those that are visible even when the person is not making any facial movements.

Neuromodulators: Not Just for Women, Growing Popularity Among Men

Contrary to popular belief, treatments for wrinkles and expression lines are not exclusive to women. An increasing number of men are undergoing procedures such as neuromodulator injections in search of solutions for facial aging.

Just as with women, this treatment is effective and safe in men, successfully reducing the visible signs of aging.

Dosage and Treatment Considerations

Duration and Frequency of Sessions

Sessions can be completed in a short time, approximately 30 minutes, as they require no hospitalization or anesthesia, making it an excellent option even for those with a busy schedule.

Since results last about four months, you will need to schedule 3 sessions per year to maintain the effects.

Treatment Personalization

An experienced professional is able to adjust the treatment according to each patient’s particular needs. Neuromodulator injections allow for dose and treatment area adjustments to achieve a personalized result that is equally effective while maintaining realistic expectations to ensure a natural appearance.

Results and Expectations

Time to See Results

Following neuromodulator injections, the effect is visible within the first 4 days, but definitive results can be observed only after day 10.

Duration of Effects

As mentioned earlier in this article, neuromodulator results can be maintained for approximately four months, although this may depend on the product, the dose used, and the treated area.

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It should be remembered that this type of substance is gradually absorbed by the body. For this reason, it begins to lose effectiveness.

When applied periodically, there is a possibility that the duration of effects may increase, potentially lasting more than six months.

Safety and Side Effects

The application of neuromodulators is a safe and effective aesthetic procedure, but it must be administered by a qualified professional to minimize risks and complications.

However, there are reduced but possible risks of experiencing redness, swelling, bruising, headaches, general malaise, and nausea. In less frequent cases, patients may experience eyelid drooping (ptosis), double vision, or difficulty swallowing.

There is also a risk of allergic reaction to the product, infection, or nerve damage.

Choosing a Professional for Treatment

As with any medical treatment, taking the time to choose the right professional is essential to ensure the success of the procedure.

The right professional for neuromodulator placement must be qualified and have experience in similar treatments. Additionally, this expert should be capable of creating a personalized treatment plan that adapts to each patient’s specific desires.

If you are considering a surgical procedure such as buccal fat removal to change your facial appearance, consult with the specialist about the compatibility of both treatments.

If you are considering neuromodulator injections, do not hesitate to contact qualified professionals who will create a personalized treatment plan for you, ensuring you achieve the rejuvenated face you desire, without the need for surgery.

Conclusion

While aging is natural in all human beings, there is a reality in today’s world where many seek to look better and better. For this reason, aesthetic treatments to eliminate wrinkles and expression lines have become increasingly popular.

Neuromodulators represent an excellent alternative. An effective and safe treatment that both men and women can use, with the advantage of showing results almost immediately and effects that last for several months.

Picture of Dr. Miguel Fernández Calderón – Plastic Surgeon

Dr. Miguel Fernández Calderón – Plastic Surgeon


Medical degree from the University of Castilla-La Mancha, with specialized training in Plastic, Aesthetic and Reconstructive Surgery at La Paz University Hospital. Member of the Spanish Society of Plastic, Reconstructive and Aesthetic Surgery (S.E.C.P.R.E)

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